Our Science
Skin longevity begins with the efficiency of its cells.
Dermoklotho is the result of over 40 years of research in molecular biology, cellular metabolism, and tissue nutrition.
The scientific project developed by Prof. Francesco Saverio Dioguardi explores the role of amino acids in the biological processes that regulate cellular energy, protein synthesis, and tissue vitality.
From this research comes the Dermoklotho approach: supporting the metabolic efficiency of cells to preserve the quality and biological balance of the skin over time.
HEAAC® Technology
Highly Efficient Amino Acid Complex
At the heart of Dermoklotho formulations is HEAAC®, a proprietary amino acid complex developed to support cellular metabolism.
Amino acids are fundamental components for cellular function: they participate in energy production, protein synthesis, and the biological defense systems of the skin.
HEAAC® provides skin cells with the essential elements needed to sustain the biological processes that regulate vitality, protection, and the structural integrity of the skin.
Cellular Energy Metabolism
Skin vitality depends on the energy of its cells.
Skin cells require energy to sustain essential biological processes such as protein synthesis, cellular repair, and tissue renewal.
This energy is produced within the mitochondria in the form of ATP, the molecule that fuels all cellular functions.
Over time, cellular energy production declines, reducing the ability of cells to maintain the biological processes essential for skin quality.
Supporting cellular energy metabolism is therefore a fundamental principle of the Dermoklotho approach.
Klotho
The Protein of Cellular Longevity
Among the key biological regulators of cellular longevity, a central role is played by the Klotho protein.
This protein is involved in the regulation of cellular metabolic processes and contributes to maintaining the balance between protein synthesis and the renewal of cellular structures. Increased expression of Klotho is associated with improved metabolic efficiency and a greater ability of cells to preserve their functionality over time.
Studies conducted within the Dermoklotho research framework indicate that HEAAC®, the proprietary amino acid complex, contributes to supporting the biological processes associated with the activity of this protein, promoting its expression in skin cells.
THE ORIGIN OF OUR SCIENCE
Prof. Francesco Saverio Dioguardi
Professor Francesco Saverio Dioguardi is internationally recognized as one of the leading authorities in the study of metabolism and nutritional therapies.
His research, developed across international academic environments, has significantly contributed to the understanding of metabolic mechanisms and the role of amino acids in human physiology.
Author of numerous international patents in the field of amino acid formulations, he is considered a pioneer in the application of biochemistry and molecular biology to medicine and clinical nutrition.
Part of Professor Dioguardi’s research has focused on skin repair processes and on the role of metabolism in tissue quality.
From the study of these mechanisms emerges a deeper understanding of how the skin regenerates, protects itself, and preserves its integrity over time.
Dermoklotho translates this knowledge into an advanced cosmeceutical approach: supporting the skin’s physiological processes, respecting its balance, and accompanying it over time.
The Dermoklotho Approach
Nourishing the skin inside and out
Dermoklotho has developed an integrated approach to skin care that acts on two biologically complementary levels.
From the outside, dermocosmetic formulations containing HEAAC®, the proprietary amino acid complex, provide skin cells with the essential elements needed to support cellular metabolism and the biological processes that contribute to maintaining the skin’s balance and vitality.
From the inside, targeted supplementation with essential amino acids supports cellular metabolism and the activity of fibroblasts, the cells responsible for producing the skin’s main structural components, such as collagen and elastin.
This synergy helps sustain the biological processes that keep the skin vital, balanced, and structurally resilient over time.
Promotes collagen and elastin synthesis
Prevents fibroblast ageing
Nourishes and strengthens epidermis cells
